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The impacts of sex on the pharmacokinetics of provigil XR have actually been investigated in Trial 1100.1486.

It functions by blocking nerve impulses (pain feelings) that are sent out to your brain.

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In people regarding mild renal impairment (baseline creatinine clearance = 30 to 50 mL/min), a dosage decrease to 75 % of the provigil beginning dose when made use of as monotherapy or in combo regarding docetaxel (from 1250 mg/m2 to 950 mg/m2 two times daily) is recommended [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)] Succeeding dosage modification is recommended as outlined in Table 2 as well as Table 3 (depending upon the routine) if an individual creates a quality 2 to 4 negative event [ see Warnings and Precautions (5.5)] The beginning dosage modification referrals for people with moderate renal problems use to both provigil monotherapy and provigil in mix usage with docetaxel.

If you do or drive anything that needs you to be alert, be cautious.